Md. Sharif Hossain, PhD

- Dedicated to research and education for the breakthrough invention and advancement of life science technology from bench to clinic.

Associate Professor and Chairman of the Department

Dept. of Biotechnology and Genetic Engineering
Jahangirnagar University
Savar, Dhaka-1342

Cell phone: +8801758832428
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Md. Sharif Hossain, PhD

Background

  • April, 2011— March, 2014: Researcher, Biomaterials Centre for Regenerative Medical Engineering, Foundation for Advancement of International Science (FAIS), Tsukuba, JAPAN 0 Human iPS cell generation and guided diftentiation for the regeneration of therapeutics cells 0 Influence of bio-nanointerface on the intracellular regulation of stem cells (ES/iPS cells) for biomedical and regenerative medicine application.
  • April , 2011— March, 2014: Post Doctoral Researcher, Department of Biomolecular Engineeting, Tokyo Institute of Technology, JAPAN. Virus free generation of Induced Pluripotent Stem (iPS) cell by genetic manipulation and purification using cell sorting on engineered extracellular matrix 0 Gene delivery to Embryonic Stan Cells for homogenous differentiation toward hepatocytes/neurons using gene/drug transporter 0 Cart= specific in vitro and in vivo delivery of functional genesidnigs
  • 2008— 2011: Doctor of Engineerhig (PhD), Department of Biomolecular Engineering, Tolcyo Institute of Technology, Japan. Drug Delivery System and Gene therapy for cancers and other genetic diseases: 0 Gene Therapy approach using small interfering RNA (siRNA) and functional DNA especially for cancer mediated by novel gene transporter (Carbonate apatite) 0 Cancer Immunotherapy based research using human T lymphocytes 0 Designing of delivery system for anti cancer therapeutics based on inorganic nanoaystals of carbonate apatite focusing on ovarian and gastruintestinal cancer (In vitro and In Wvo)
  • 2006-2008: Master of Engineerhig (Master), Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan as Monbukagakusho Scholar Focused on Biomaterials design for tissue engineering and drug delivery system
  • 2005-2006: Research Student, Department of Biomolecular Engineering and Biotechnology, Tokyo Institute of Technology B Achieved the certificate of Professional Japanese language course Jl and J2 B Successfully completed the research studentship in the field of Biomolecular Engineering
  • 1998-2003: Bachelor of Science (B.Sc.): Biotechnology and Genetic Engineering, Khulna University, Bangladesh Bachelor thesis title: Prevalence of Hepatitis B virus surface antigen (H BsAg) in transport workers of Khulna region. Biotechnology and Genetic Engineering Discipline Khulna University, BANGLADESH.

Selected Publications View All

  1. 1

    Adnan N, Mie M, Haque A, Hossain S, Mashimo Y, Akaike T, Kobatake E., Construction of a Defined Biomimetic Matrix for Long-Term Maintenance of Mouse Induced Pluripotent Stem Cells, ACS Bioconjug Chem., 27(7):1599-605, July 20, 2016. Impact Factor: 4.500

  1. 2

    Haque A, Adnan N, Motazedian A, Akter F, Hossain S, Kutsuzawa K, Nag K, Kobatake E, Akaike T, An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors, PLoS One, 10(8):e0135170, August 05, 2015. Impact Factor: 4.092

  1. 3

    Wu X, Yamamoto H, Nakanishi H, Yamamoto Y, Inoue A, Tei M, Hirose H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Hossain S, Akaike T, Matsuura N, Doki Y, Mori M, Innovative delivery of siRNA to solid tumors by super carbonate apatite, PLoS One, 10(3):e0116022, March 04, 2015. Impact Factor: 4.092

  1. 4

    Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.

  1. 5

    Juntaro Matsuzaki, Hidekazu Suzuki, Hitoshi Tsugawa, Mitsuhiro Watanabe, Sharif Hossain, Eri Arai, Yoshimasa Saito, Shigeki Sekine, Toshihiro Akaike, Yae Kanai, Ken-ichi Mukaisho, Johan Auwerx, Toshifumi Hibi, Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis, Gastroenterology, 145(6):1300-11, 2013 Dec. Impact Factor: 16.761

  1. 6

    Hossain S, Yamamoto H, Chowdhury EH, Wu X, Hirose H, Haque A, Doki Y, Mori M, Akaike T, Fabrication and intracellular delivery of Doxorubicin/Carbonate Apatite Nanocomposites: Effiect on growth retardation of established Colon Tumor, PLoS One, 8(4):e60428, 2013. Impact Factor: 4.092

  1. 7

    Hossain S*, Nag K*, (*equal contribution), Naznin S, Chowdhury EH, PKC activation promotes internalization of DNA-immobilized inorganic nano-crystals by clathrin-dependent endocytosis for efficient transgene expression in human lymphocytes, Journal of Nanomedicine and Nanotechnology, 4:174, 2013. Impact Factor: 5.72

  1. 8

    Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013. (BOOK CHAPTER)

  1. 9

    Stanislaus A, Kunnath AP, Tiash S, Fatemian T, Kamaruzman NI, Bakhtiar A, Mustak S, Hossain S, Akaike T, Chowdhury EH, Intracellular delivery of NF-κB small interfering RNA for modulating therapeutic activities of classical anti-cancer drugs in human cervical cancer cells, Drugs and Therapy Studies, 3(1):e7, 2013. DOI: http://dx.doi.org/10.4081/dts.2013.e7

  1. 10

    Stanislaus A, Bakhtiar A, Salleh D, Tiash S, Fatemian T, Hossain S, Akaike T, Chowdhury EH, Knockdown of PLC-gamma-2 and calmodulin 1 genes sensitizes human cervical adenocarcinoma cells to doxorubicin and paclitaxel, Cancer Cell Int., 12(1):30, 2012. Impact Factor: 2.09

  1. 11

    Hossain S, Chowdhury EH, Akaike T, Nanoparticles and toxicity in therapeutic delivery: the ongoing debate, Therapeutic Deliv., 2(2): 125-132, 2011. (EDITORIAL)

  1. 12

    Haque A, Hexig B, Meng Q, Hossain S, Nagaoka M, Akaike T, The effect of recombinant E-cadherin substratum on the differentiation of endoderm-derived hepatocyte-like cells from embryonic stem cells, Biomaterials, 32(8): 2032-42, 2011. Impact Factor: 7.604

  1. 13

    Stanislaus A, Hossain S, Chua MJ, Kunnath AP, Wen QC, Syakira SN, Siong GY, Loong SW, Othman I, Akaike T, Chowdhury EH, Fabrication and intracellular delivery of siRNA/carbonate apatite nano-composites for effective knockdown of cyclin B1 gene, Drugs and Therapy Studies, 1(1): 26-30, 2011.

  1. 14

    Hossain S, Stanislaus A, Chua MJ, Tada S, Tagawa Y, Chowdhury EH, Akaike T, Carbonate apatite-facilitated intracellularly delivered siRNA for efficient knockdown of functional genes, J. Control. Release, 147(1): 101-108, 2010. Impact Factor: 7.633

  1. 15

    Hossain S, Tada S, Akaike T, Chowdhury EH, Influences of electrolytes and glucose on formulation of carbonate apatite nanocrystals for efficient gene delivery to mammalian cells, Anal. Biochem. 397: 156–161, 2010. Impact Factor: 2.582

  1. 16

    Hossain S, Akaike T, Chowdhury EH, Current approaches for drug delivery to central nervous system, Curr. Drug Deliv., 7(5):389-397, 2010.

  1. 17

    Kutsuzawa Koichi, Chowdhury E.H., Tada seiichi, Fatema T. Zohra, Sharif Hossain, Akaike Toshihiro. Intracellular Delivery of protein, RNA and gene using nano particles of carbonate apatite: Frontier for molecular and cellular therapy, Chapter 1 (3), Drug Delivery System (DDR), 28-35, 2010.

  1. 18

    Kutsuzawa K, Tada S, Hossain S, Akaike T, Chowdhury EH, Disrupting actin filaments promotes efficient transfection of a leukemia cell line using cell adhesive protein-embedded carbonate apatite particles, Anal. Biochem. 388: 164 -166, 2009. Impact Factor: 2.582

  Others         Comments about my novel research: (from Editor in chief, Journal of Controlled Release)
  1. 19

    Park K. Carbonate apatite-facilitated intracellular delivery of siRNA. J Control Release. 147(1):1, 2010. Impact Factor: 7.633                                                                                                                   Special editorial publication for award: 

  2. 20

    Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite. Nucleic Acids Res., 37 (22): 7347-7348, 2009. Impact Factor: 8.278

Documents View All

Books View All

  1. Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.
  2. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013.

Conference paper View All

  1. Sharif Hossain, and T. Akaike, pH-sensitive Nano-crystals of Carbonate Apatite for Smart and Efficent Drug/ transgene Delivery, Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 21 – 24, 2013, Honolulu, Hawaii, USA.
  2. S. Hossain and T. Akaike, Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix facilitated by Bio-functionalized Nanoparticles of Carbonate Apatite, Proceedings of the 3rd TERMIS World Congress 2012, September 5- 8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6(1); 292-293, 2012).
  3. K. Arai, T. Adachi, S. Hossain, T. Akaike, M. Nakamura, Establishment of 3D culture system for primary hepatocytes, ‘Regulation of cell membrane polarity for tissue engineering’, Proceedings of the 3rd TERMIS World Congress 2012, September 5-8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6 (1); 342-343, 2012).
  4. Sharif Hossain and Toshihiro Akaike, Novel pH-sensitive Carbonate Apatite Nanoparticles as Intracellular Gene/Drug Transporter, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  5. Sharif Hossain and Toshihiro Akaike, Bio-functionalized pH-sensitive Carbonate Apatite Nanoparticles Facilitated Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  6. Sharif Hossain and Toshihiro Akaike, Design of super effective pH sensitive carbonate apatite nanoparticles as intracellular gene/drug transporter, 3rd Asian Biomaterial Congress, September15-17, 2011, Busan, Republic of Korea.
  7. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Effective gene knockdown with carbonate apatite-facilitated intracellularly delivered siRNA, Proceedings of the 37th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 10 – 14, 2010, Portland, Oregon, USA.
  8. Sharif Hossain and Toshihiro Akaike, Efficient Delivery of siRNA by pH Sensitive Nanocrystals of Carbonate Apatite, Proceedings of the 49th Annual Meeting of American Society of Cell Biology, from December 5-9, 2009, San Diego, California, USA.
  9. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 5th Annual Meeting of Oligonucleotide Therapeutic Society and 19th Antisense symposium, November 3-6, 2009, Fukuoka, Japan.
  10. Sharif Hossain and Toshihiro Akaike, Design of an Efficient pH Sensitive Delivery System for Anticancer Drugs Based on Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 2nd TERMIS World Congress, August 31-September 3, 2009, Seoul, Republic of Korea.
  11. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of an efficient pH sensitive delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 35th Annual Meeting & Exposition of the Controlled Release Society, July 12-16, 2008, New York, USA.
  12. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of a smart delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 8th World Biomaterial Congress, May 28 – June 01, 2008, Amsterdam, The Netherlands.

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Sharif Hossain

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