Md. Sharif Hossain, PhD

- Dedicated to research and education for the breakthrough invention and advancement of life science technology from bench to clinic.

Chairman of the Department, and Associate Professor

Dept. of Biotechnology and Genetic Engineering
Jahangirnagar University
Savar, Dhaka-1342

Cell phone: +8801758832428
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Md. Sharif Hossain, PhD

Background

BIOGRAPHY:

Dr. Md. Sharif Hossain is an Associate Professor at the Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh. He is dedicated to research and education for the breakthrough invention and advancement of life science technology from bench to clinic.

After completing his secondary and tertiary level education from Bangladesh, he moved to Japan and achieved his M.Sc. and Ph.D. degree from the Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology in 2008 and 2011 respectively as MEXT (The Ministry of Education, Culture, Sports, Science and Technology, Japan) scholar. He was then awarded prestigious Postdoctoral Fellowship of Japan Society for the Promotion of Science (JSPS) and conducted cutting edge research at Frontier Research Centre, Tokyo Institute of Technology, Japan (2011~2013). In 2014, he joined as Senior Researcher at Biomaterials Centre for Regenerative Medical Engineering, Foundation for Advancement of International Science (FAIS), Tsukuba, Japan. By August 2014, he moved to Bangladesh and joined as an Assistant Professor at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University. He also served as the chairman at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University and successfully completed his tenure from July 2017 to July 2020.

Dr. Hossain’s research interest includes the field of nanobiotechnology, drug development, biomaterials design and regenerative medicine. He developed novel nonviral vector effective for cancer gene therapy and drug delivery. Moreover, he conducted cutting edge research to develop mammalian induced pluripotent stem (iPS) cell generation and guided differentiation for the regeneration of therapeutics cells. He also focused the influence of nano-biointerface on the intracellular regulation of stem cells (ES/iPS cells) for regenerative medicine and biomedical application. His current research focuses on the nanobiotechnology based approaches to overcome the challenges of antibiotic resistance. He has published more than 25 articles in peer reviewed international journals, 2 book chapters and 12 international conferences papers.

He was the recipients of MEXT scholarship (The Ministry of  Education, Culture, Sports, Science and Technology, Japan) (2005~2011), Prestigious Fellowship of Japan Society for the Promotion of Science (JSPS) (2011~ 2013), Nucleic Acids Research Award (NAR Award) and Antisense (Kawahara) Award from Oligonucleotide Therapeutic Society, OTS (USA) (2009), Award of Excellence from Toin International Symposium on Biomedical Engineering, (Japan) (2007), Murakami Scholarship, Tokyo Institute of Technology, (Japan) (2008~ 2011), Bangladesh Education Leadership Award as Best Professor in Genetic Engineering Studies  from World Education Congress (2019).

 

EDUCATION:

1995, Secondary School Certificate (SSC), Dawood Public School, Jessore, Bangladesh

1995 ~ 1997, Higher Secondary Certificate (HSC), Cantonment College, Jessore, Bangladesh

1998 ~ 2003, Bachelor of Science (BSc), Biotechnology and Genetic Engineering Discipline, Khulna University, Bangladesh 

2005 ~ 2006, Research Student, Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan 

2006 ~ 2008, Master of Engineering (MSc), Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan

2008 ~2011, Doctor of Engineering (PhD), Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan 

2011/04/01~ 2011/08/31, Postdoctoral Fellow, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan

2011/09/01~ 2013/08/31, Foreign Researcher of Japan Society for the Promotion of Science (JSPS), Frontier Research Centre, Tokyo Institute of Technology, Japan

2013/09/01~ 2014/03/31, Scientific Research Fellow, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan

 

EMPLOYMENT

2014/04/01~ 2014/08/08, Senior Scientist, Biomaterials Centre for Regenerative Medical Engineering, Foundation for Advancement of International Science (FAIS), Tsukuba, JAPAN

2014/08/09~ 2017/01/30, Assistant Professor, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka-1342, BANGLADESH

2017/01/31~ Continuing : Associate Professor, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka-1342, BANGLADESH

 

RESEARCH HIGHLIGHTS

  • August, 2014- Continuing: Assistant Professor and Associate Professor, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka-1342, BANGLADESH, Nanobiotechnology based approaches to overcome the challenges of antibiotic resistance, Drug development, Biomaterials Design, Regenerative medicine.
  • April, 2014— August, 2014: Senior Scientist, Biomaterials Centre for Regenerative Medical Engineering, Foundation for Advancement of International Science (FAIS), Tsukuba, JAPAN,  Human iPS cell generation and guided differentiation for the regeneration of therapeutics cells,  Influence of bio-nanointerface on the intracellular regulation of stem cells (ES/iPS cells) for biomedical and regenerative medicine application.
  • April , 2011— March, 2013: JSPS Post Doctoral Researcher, Department of Biomolecular Engineeting, Tokyo Institute of Technology, JAPAN. Virus free generation of Induced Pluripotent Stem (iPS) cell by genetic manipulation and purification using cell sorting on engineered extracellular matrix 0 Gene delivery to Embryonic Stan Cells for homogenous differentiation toward hepatocytes/neurons using gene/drug transporter, specific in vitro and in vivo delivery of functional gene
  • 2008— 2011: Doctor of Engineering (PhD), Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan. Drug Delivery System and Gene therapy for cancers and other genetic diseases: 0 Gene Therapy approach using small interfering RNA (siRNA) and functional DNA especially for cancer mediated by novel gene transporter (Carbonate apatite),  Cancer Immunotherapy based research using human T lymphocytes, Designing of delivery system for anti cancer therapeutics based on inorganic nanoaystals of carbonate apatite focusing on ovarian and gastruintestinal cancer (In vitro and In Vivo) funded by Monbukagakusho Scholarship
  • 2006-2008: Master of Engineering (Master), Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan under Monbukagakusho Scholarship Focused on Biomaterials design for tissue engineering and drug delivery system
  • 2005-2006: Research Student, Department of Biomolecular Engineering and Biotechnology, Tokyo Institute of Technology B Achieved the certificate of Professional Japanese language course Jl and J2 B Successfully completed the research studentship in the field of Biomolecular Engineering
  • 1998-2003: Bachelor of Science (B.Sc.): Biotechnology and Genetic Engineering, Khulna University, Bangladesh Bachelor thesis title: Prevalence of Hepatitis B virus surface antigen (H BsAg) in transport workers of Khulna region. Biotechnology and Genetic Engineering Discipline Khulna University, BANGLADESH.

 

 

AWARDS & HONORS:

  • Awarded Bangladesh Education Leadership Award as Best Professor in Genetic Engineering Studies  from World Education Congress 2019, Bangladesh.
  • Served as the Chairman at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Bangladesh  and successfully completed his tenure from July 2017 to July 2020.
  • Awarded Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship, JAPAN
  • Achieved the Nucleic Acids Research Award (NAR Award) and Antisense (Kawahara) Award from Oligonucleotide Therapeutic Society, OTS (USA), Link- http://www.oxfordjournals.org/our_journals/nar/award_winners.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794151/
  • Awarded Monbukagakusho Scholarship, Japan (Japan Embassy/Bangladesh Government Selection) from 2005-2011, Japan.
  • Received Award of Excellence for best presentation in Toin International Symposium on Biomedical Engineering 2007, in Yokohama, Japan.
  • Awarded Murakami Scholarship, Tokyo Institute of Technology (2008~ 2011), Japan.
  • Obtained University Distinction Marks  in the Bachelor of Science (B.Sc.) in Biotechnology and Genetic Engineering, Khulna University, Bangladesh.
  • Achieved Education Board Scholarship (Jessore Board) 1995, 1997, Bangladesh.
  • Obtained Primary and Junior Scholarship, Bangladesh.

 

SOCIETY ACTIVITY:

  • Controlled Release Society, USA(CRS)
  • TERMIS (Tissue Engineering International Regenerative Medicine Society)
  • Oligonucleotide Therapeutic Society, USA (OTS)
  • American Society of Cell Biology, USA (ASCB)
  • Japan Society of drug delivery system, JAPAN
  • Japanese Society for Biomaterials, JAPAN

 

LIST OF THE INTERNATIONAL SCIENTIFIC AND COLLABORATIVE MEETING ATTENDED

  • Tokyo Tech- McMaster University Collaborative Meeting, From July 14- 16, 2010, Hamilton, Ontario, Canada
  • Tokyo Tech- Mahidol University Joint Symposium, from July 31- August 2, 2008, Bangkok, Thailand.
  • The 3rd Scientific Meeting of the Asian Society for Vascular Biology, from August 4-5, 2008, Singapore city, Singapore

Selected Publications View All

  1. 1

    Bakul Akter, Ariful Islam Khan · Subarna Karmaker · Pollob Ghosh · Soma Saha · Shakil Ahmed Polash · Zinia Islam · Satya Ranjan Sarker · Md. Sharif Hossain · Hiroyuki Yasui · Tapan Kumar Saha, Chelation of zinc(II) with poly(γ‑glutamic acid) in aqueous solution: kinetics, binding constant, and its antimicrobial activity, Polymer Bulletin, https://doi.org/10.1007/s00289-020-03165-9 Received: 28 November 2019 / Revised: 2 March 2020 / Accepted: 10 March 2020, Impact Factor: 1.858

  2. 2

    Saiful Islam, Md. Ahsanul Kabir, Md. Faizul Hossain Miraz, Effat Jahan Tamanna, Satya Ranjan Sarker, Zinia Islam, S. M. Jahangir Hossain, Sharif Hossain*, Gautam Kumar Deb* (* Corresponding Author), Investigation of Ovarian Follicular Waves and Major Hormonal Profile in Red Chittagong Cattle, Advances in Bioscience and Biotechnology, 2020, 11, 7- 2.

  3. 3

    Hossain MM, Polash SA, Takikawa M, Shubhra RD, Saha T, Islam Z, Hossain S, Hasan MA, Takeoka S, Sarker SR, Investigation of the Antibacterial Activity and in vivo Cytotoxicity of Biogenic Silver Nanoparticles as Potent Therapeutics, Front Bioeng Biotechnol. 2019 Oct 9;7:239. Impact Factor: 5.122

  4. 4

    Razib Datta Shubhra, Shakil Ahmed Polash, Tanushree Saha, Ashraful Hasan, Sharif Hossain, Zinia Islam*, Satya Ranjan Sarker* (* Corresponding Author), Investigation of the Phytoconstituents and Antioxidant Activity of Diospyros malabarica Fruit Extracts, Advances in Bioscience and Biotechnology, 2019, 10, 431-454.

  5. 5

    Ratna Mondal, Shakil Ahmed Polash, Tanushree Saha, Zinia Islam, Md. Maniruzzaman Sikder, Nuhu Alam, Md. Sharif Hossain*, Satya Ranjan Sarker* (* Corresponding Author), Investigation of the Phytoconstituents and Bioactivity of Various Parts of Wild Type and Cultivated Phyllanthus emblica L., Advances in Bioscience and Biotechnology, 8, 211-227, 2017.

  6. 6

    Shakil Ahmed Polash, Tanushree Saha, Md. Sharif Hossain and Satya Ranjan Sarker, Phytochemical contents, antioxidant and antibacterial activity of the ethanolic extracts of Centella asiatica (L.) Urb. leaf and stem, J U J. Biol. Sci., 2017 (June), 6(1): 51-57.

  7. 7

    Shakil Ahmed Polash, Tanushree Saha, Md. Sharif Hossain, Satya Ranjan Sarker, Investigation of the Phytochemicals, Antioxidant, and Antimicrobial Activityof theAndrographispaniculata Leaf andStem Extracts, Advances in Bioscience and Biotechnology, 2017, 8, 149-162.

  8. 8

    Adnan N, Mie M, Haque A, Hossain S, Mashimo Y, Akaike T, Kobatake E., Construction of a Defined Biomimetic Matrix for Long-Term Maintenance of Mouse Induced Pluripotent Stem Cells, ACS Bioconjug Chem., 27(7):1599-605, July 20, 2016. Impact Factor: 4.349

  9. 9

    Haque A, Adnan N, Motazedian A, Akter F, Hossain S, Kutsuzawa K, Nag K, Kobatake E, Akaike T, An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors, PLoS One, 10(8):e0135170, August 05, 2015. Impact Factor: 4.092

  10. 10

    Wu X, Yamamoto H, Nakanishi H, Yamamoto Y, Inoue A, Tei M, Hirose H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Hossain S, Akaike T, Matsuura N, Doki Y, Mori M, Innovative delivery of siRNA to solid tumors by super carbonate apatite, PLoS One, 10(3):e0116022, March 04, 2015. Impact Factor: 4.092

  11. 11

    Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.

  12. 12

    Juntaro Matsuzaki, Hidekazu Suzuki, Hitoshi Tsugawa, Mitsuhiro Watanabe, Sharif Hossain, Eri Arai, Yoshimasa Saito, Shigeki Sekine, Toshihiro Akaike, Yae Kanai, Ken-ichi Mukaisho, Johan Auwerx, Toshifumi Hibi, Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis, Gastroenterology, 145(6):1300-11, 2013 Dec. Impact Factor: 19.233

  13. 13

    Hossain S, Yamamoto H, Chowdhury EH, Wu X, Hirose H, Haque A, Doki Y, Mori M, Akaike T, Fabrication and intracellular delivery of Doxorubicin/Carbonate Apatite Nanocomposites: Effiect on growth retardation of established Colon Tumor, PLoS One, 8(4):e60428, 2013. Impact Factor: 4.092

  14. 14

    Hossain S*, Nag K*, (*equal contribution), Naznin S, Chowdhury EH, PKC activation promotes internalization of DNA-immobilized inorganic nano-crystals by clathrin-dependent endocytosis for efficient transgene expression in human lymphocytes, Journal of Nanomedicine and Nanotechnology, 4:174, 2013. Impact Factor: 3.57

  15. 15

    Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013. (BOOK CHAPTER)

  16. 16

    Stanislaus A, Bakhtiar A, Salleh D, Tiash S, Fatemian T, Hossain S, Akaike T, Chowdhury EH, Knockdown of PLC-gamma-2 and calmodulin 1 genes sensitizes human cervical adenocarcinoma cells to doxorubicin and paclitaxel, Cancer Cell Int., 12(1):30, 2012. Impact Factor: 3.618

  17. 17

    Hossain S, Chowdhury EH, Akaike T, Nanoparticles and toxicity in therapeutic delivery: the ongoing debate, Therapeutic Deliv., 2(2): 125-132, 2011. (EDITORIAL)Impact Factor: 2.12

  18. 18

    Haque A, Hexig B, Meng Q, Hossain S, Nagaoka M, Akaike T, The effect of recombinant E-cadherin substratum on the differentiation of endoderm-derived hepatocyte-like cells from embryonic stem cells, Biomaterials, 32(8): 2032-42, 2011. Impact Factor: 10.273

  19. 19

    Hossain S, Stanislaus A, Chua MJ, Tada S, Tagawa Y, Chowdhury EH, Akaike T, Carbonate apatite-facilitated intracellularly delivered siRNA for efficient knockdown of functional genes, J. Control. Release, 147(1): 101-108, 2010. Impact Factor: 8.375

  20. 20

    Hossain S, Tada S, Akaike T, Chowdhury EH, Influences of electrolytes and glucose on formulation of carbonate apatite nanocrystals for efficient gene delivery to mammalian cells, Anal. Biochem. 397: 156–161, 2010. Impact Factor: 2.507

  21. 21

    Hossain S, Akaike T, Chowdhury EH, Current approaches for drug delivery to central nervous system, Curr. Drug Deliv., 7（5）:389－397, 2010.Impact Factor: 1.709

  22. 22

    Kutsuzawa K, Tada S, Hossain S, Akaike T, Chowdhury EH, Disrupting actin filaments promotes efficient transfection of a leukemia cell line using cell adhesive protein-embedded carbonate apatite particles, Anal. Biochem. 388: 164 -166, 2009. Impact Factor: 2.507

  23. 23

    Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite. Nucleic Acids Res., 37 (22): 7347-7348, 2009 Special editorial publication for award. Impact Factor: 11.147

  24. 24

    Afrin,N., Sikder,M.M., Hossain,M.S. and Shilpi,R.Y., Bacillus cereus strain JUB1 16S ribosomal RNA gene, partial sequence, GenBank Accession of bacterial sequences, GenBank: MH552993.1, 2018.

  25. 25

    Afrin,N., Sikder,M.M., Hossain,M.S. and Shilpi,R.Y., Bacillus cereus strain JUB2 16S ribosomal RNA gene, partial sequence, GenBank Accession of bacterial sequences, GenBank: MH552994.1, 2018.

  26. 26

     Comments about my novel research: (from Editor in chief, Journal of Controlled Release) Park K. Carbonate apatite-facilitated intracellular delivery of siRNA. J Control Release. 147(1):1, 2010. Impact Factor: 8.375                                                                                                            

Documents View All

Books View All

  1. Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.
  2. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013.

Conference paper View All

  1. Sharif Hossain, and T. Akaike, pH-sensitive Nano-crystals of Carbonate Apatite for Smart and Efficient Drug/ transgene Delivery, Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 21 – 24, 2013, Honolulu, Hawaii, USA.
  2. S. Hossain and T. Akaike, Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix facilitated by Bio-functionalized Nanoparticles of Carbonate Apatite, Proceedings of the 3rd TERMIS World Congress 2012, September 5- 8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6(1); 292-293, 2012).
  3. K. Arai, T. Adachi, S. Hossain, T. Akaike, M. Nakamura, Establishment of 3D culture system for primary hepatocytes, ‘Regulation of cell membrane polarity for tissue engineering’, Proceedings of the 3rd TERMIS World Congress 2012, September 5-8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6 (1); 342-343, 2012).
  4. Sharif Hossain and Toshihiro Akaike, Novel pH-sensitive Carbonate Apatite Nanoparticles as Intracellular Gene/Drug Transporter, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  5. Sharif Hossain and Toshihiro Akaike, Bio-functionalized pH-sensitive Carbonate Apatite Nanoparticles Facilitated Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  6. Sharif Hossain and Toshihiro Akaike, Design of super effective pH sensitive carbonate apatite nanoparticles as intracellular gene/drug transporter, 3rd Asian Biomaterial Congress, September15-17, 2011, Busan, Republic of Korea.
  7. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Effective gene knockdown with carbonate apatite-facilitated intracellularly delivered siRNA, Proceedings of the 37th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 10 – 14, 2010, Portland, Oregon, USA.
  8. Sharif Hossain and Toshihiro Akaike, Efficient Delivery of siRNA by pH Sensitive Nanocrystals of Carbonate Apatite, Proceedings of the 49th Annual Meeting of American Society of Cell Biology, from December 5-9, 2009, San Diego, California, USA.
  9. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 5th Annual Meeting of Oligonucleotide Therapeutic Society and 19th Antisense symposium, November 3-6, 2009, Fukuoka, Japan.
  10. Sharif Hossain and Toshihiro Akaike, Design of an Efficient pH Sensitive Delivery System for Anticancer Drugs Based on Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 2nd TERMIS World Congress, August 31-September 3, 2009, Seoul, Republic of Korea.
  11. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of an efficient pH sensitive delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 35th Annual Meeting & Exposition of the Controlled Release Society, July 12-16, 2008, New York, USA.
  12. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of a smart delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 8th World Biomaterial Congress, May 28 – June 01, 2008, Amsterdam, The Netherlands.

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